tatCD [2018-05-28 09:34:52]

component of the TatAD-TatCD twin-arginine translocase

Locus: BSU02640

Isoelectric point: 9.34

Molecular weight: 27.96 kDa

Protein length: 245 aa

Gene length: 735 bp

Function: TAT protein secretion

Product: component of the twin-arginine translocation pathway

Essential: no

Synonyms: ycbT

Genomic Context

Loading

Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Phosphate metabolism
• Information processing → Protein synthesis, modification and degradation → Protein secretion
• Groups of genes → Membrane proteins

Gene

Coordinates: 286,048 → 286,776

The protein

Catalyzed reaction/ biological activity

• translocation of PhoD PubMed

Protein family

• tatC family (according to Swiss-Prot)

Paralogous protein(s)

• TatCY

Structure

• 4B4A (32% identity)

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: phoD-tatAD-tatCD
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • PhoP: activation, PubMed, in PhoP regulon

  Regulation

  • expressed under conditions of phosphate limitation (PhoP) PubMed

  Additional information

  • expression of the operon depends on functional HemAT and CsbC PubMed

Biological materials

Mutant

• MGNA-C038 (ycbT::erm), available at the NBRP B. subtilis, Japan
• BKE02640 (ΔtatCD::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTCAAAAAAGCCCTCCCT, downstream forward: _UP4_AGGGAAGAAACAGCGGCGGC
• BKK02640 (ΔtatCD::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTCAAAAAAGCCCTCCCT, downstream forward: _UP4_AGGGAAGAAACAGCGGCGGC

Labs working on this gene/protein

• Oscar Kuipers, University of Groningen, The Netherlands
• Homepage

References

Reviews

Loading

Original publications

Loading